Here are all the contraindications of branched chain amino acids explained clearly and simply
Before understanding the contraindications of branched chain amino acids, let's see how they are absorbed by our body.
Unlike the proteins that we ingest and which undergo a first digestion in the stomach, by ingesting an amino acid-based supplement they are immediately absorbed, so after reaching the liver, they are redistributed to the general circulation and can be used for the synthesis of new ones. tissue proteins, the synthesis of plasma proteins, used to be inserted into the lipid metabolic pathway or to be used for energy production.
If amino acids are not used for protein synthesis, they are oxidized directly or transformed into glycides and lipids.
In both cases, the body must remove the amino group and carry out this operation through processes that take the name of amino acid desamination (hydrolytic, oxidative and reductive desamination), transamination (transport of the amino group by specific transaminases) and decarboxylation (transformation of amino acids into primary amines).
The dissolution of the amino group leads to the creation of ammonia which is then released by the body, partly through the urine, partly through its transformation in the liver into urea, which in turn is always eliminated in the urine.
Now if you have read so far it is clear that an excessive ingestion of branched chain amino acids leads to a surplus of work for the liver and kidneys.
It is no coincidence that many of the first symptoms, in the case of high ingestion of branched chain amino acids, are the enlarged figato, and then pass, in the most extreme cases, to renal failure.
For this reason it is always good to consult with your doctor before proceeding with the intake of branched chain amino acids.